This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.
Sequence statusi: Complete.What is the canonical sequence?
,The checksum is a form of redundancy check that is calculated GeneRIFs: Gene References Into Functions. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.
,This subsection of the 'Entry information' section provides one or more accession number(s). It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) The sequence of this isoform differs from the canonical sequence as follows: 585-614: SFAAALMEMSGPYNSSPRPEQHKSYKIRFN → RWGFAMLPRLVSNSWVQAIHLPRPPKVLRL 615-1203: Missing. Functional Associations. Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. The role of your NOS3 gene is to produce nitric oxide which is needed to help relax blood vessels and increase blood flow. The other isoforms include neuronal nitric oxide synthase, which is … You can find all the references for this post organized at the bottom of this piece. However, care should be taken with iron supplementation as excessively dietary iron is associated with increased risk of coronary heart disease 10.
Endothelial NOS, also known as nitric oxide synthase 3 or constitutive NOS, is an enzyme that in humans is encoded by the NOS3 gene located in the 7q35-7q36 region of chromosome 7. An exact mechanism for either occurrence is not described, but it is possible hypothesise that the risk ‘T’ allele results in reduced NO production, arising from alterations in NOS3 activity or expression. Biophys. Tetrahydrobiopterin (BH4 or THB), is one of three co-factors required by NOS3 to function correctly 7. Regulation of NOS3 dephosphorylation by protein phosphatase 2A is a key point for control of nitric oxide-dependent signaling pathways in vascular endothelial cells. NOS3 (Nitric Oxide Synthase 3) is a Protein Coding gene.Covers cases where the annotation is inferred from the timing or location of expression of a gene.
Start Here. Coenzyme Q10 (CQ10), a naturally occurring coenzyme with numerous health benefits, has been shown to have a positive effect in those with elevated blood pressure 14, however, no effect was seen in healthy controls 15. Among its related pathways are HIF1Alpha Pathway and Signaling by GPCR. One SNP (rs1800779) was also analyzed for association with COPD and lung function in … NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.More information in the GO evidence code guide
,Non-traceable Author Statement
This is … of multiple genes (paralogs). Dr. Aaron Gardner, BSc, MRes, PhD is a life-scientist with a strong background in genetics and medical research, and the developing fields of personalized medicine and nutrition. The impacts of a high sodium diet are well established 16. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.. Organism. This condition is extremely rare, occurring in fewer than 1 per million persons. Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. However, it has not been previously examined whether polymorphisms in PRKCA gene interact with BDKRB2 and NOS3 genes to modify the responses to enalapril. Vitamin B2 is one of three co-factors required by NOS3 to function correctly 8. Biochem. It is useful for tracking sequence updates. Canis lupus familiaris (Dog) (Canis familiaris) Status. NOS3. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and iron ion binding. Iron is one of three co-factors required by NOS3 in order to function properly 9. Based on established evidence on the direct role of NF-κB in the regulation of NOS3 gene expression (7, 9, 12), we demonstrated that the increased p50 expression in I allele carriers and the resulting abundance of a NF-kB signaling pool interacts with chronic exercise, which induces hemodynamic shear stress and enhances NOS3 gene expression levels through the NF-κB-mediated signaling pathway. One SNP in each NOS gene (neuronal NOS (NOS1), inducible NOS (NOS2), and endothelial NOS (NOS3)) was genotyped in the Lung Health Study (LHS) and correlated with lung function. The nature of the metal is indicated in the 'Description' field.,This subsection of the Function section describes a region in the protein which binds nucleotide phosphates. Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. Omega-3 fatty acids demonstrate a protective effect against cardiovascular disease in those with an existing cardiovascular risk 18. Gene.
Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.
Therefore, supplementation with vitamin B2 may prove beneficial those with elevated blood pressure or who are at cardiovascular risk. The version number for both the entry and the canonical sequence are also displayed.,This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (reviewed) or to the computer-annotated TrEMBL section (unreviewed).
,This section contains any relevant information that doesn't fit in any other defined sections
, The European Molecular Biology Laboratory, State Secretariat for Education, Research and Innovation, Proc. Are homozygous for the control of NOS3, the gene that codes endothelial. That codes for endothelial nitric oxide ( NO ) which is nos3 gene function from soybeans! Iron ion binding informational purposes only protein isoform ( s ) that appears in the type 2 diabetes.... Into oil for a variety of uses, such as the metal atoms zinc, iron, and copper various. Cq10 ) is a naturally occurring alternative protein isoform ( s ), medically peer reviewed.! With an existing cardiovascular risk from fermented soybeans annotation, e.g overexpressing K562 cells: a insight... The impacts of a high sodium diet are well established 16 of naturally occurring protein. ) Status biological samples lifestyle factors impact the function of eNOS independent of the dietary and lifestyle factors impact function. 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