scutellaria baicalensis root extract side effects

Am J Chin Med 2008;36(3):517-540. View abstract. View abstract. Orzechowska B, Chaber R, Wisniewska A, et al. 2008;6(1):103-8. Z., Jing, X. L., Guo, X. H., and Zhu, Y. Y. December 19, 2017. There is concern that it might cause extra bleeding during and after surgery. The antiinflammatory and analgesic effects of baicalin in carrageenan-evoked thermal hyperalgesia. View abstract. View abstract. Safety, tolerability, and pharmacokinetics of oral baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled multiple-ascending-dose study. View abstract. Martin, J. and Dusek, J. Flavonoid accumulation in Scutellaria baicalensis Georgii in vitro cultures upon treatment with sodium cinnamate. Song, S. H. and Wang, Z. View abstract. Neurosci Lett. Talk with your healthcare provider before using this product if you are taking lithium. Journal of Chinese medicinal materials 2002;25(6):451-453. WebScutellaria baicalensis Root Dry No Data Extract 100 4. Scutellaria barbata is a perennial herb that is used along with other botanicals in traditional Chinese medicine to treat bacterial infections, hepatitis, and tumors. Tong, R., Mehendale, S. R., Wang, C. Z., Shao, Z., and Yuan, C. S. Comparison of antioxidant effects of various Scutellaria baicalensis fractions and the potential role of catalase upregulation. Scutellaria baicalensis root is a plant/plant extract used in some OTC (over-the-counter) products. Treatment of acute bronchiolitis with Chinese herbs. 1. Levy RM, Khokhlov A, Kopenkin S, et al. Here we will discuss the most prominent benefits of the medicine. J Cell Biochem 10-1-2010;111(2):274-283. Wang, H. W., Lin, C. P., Chiu, J. H., Chow, K. C., Kuo, K. T., Lin, C. S., and Wang, L. S. Reversal of inflammation-associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by wogonin and chrysin. View abstract. 2019;133:109402. View abstract. Taking Baikal skullcap along with diabetes medications might cause your blood sugar to go too low. BMC.Complement Altern Med 2006;6:27. This information may not fit your specific health circumstances. We currently have no information for BAIKAL SKULLCAP overview. J Cell Biochem 10-1-2010;111(2):274-283. Che, Q. M., Huang, X. L., Li, Y. M., Kun, Z., Teruaki, A., and Masao, H. [Studies on metabolites of baicalin in human urine]. See additional information. Maternal and Child Health Care of China 2011;26(10):1529-1531. You are hereby advised to consult with a physician or other professional health-care provider prior to making any decisions, or undertaking any actions or not undertaking any actions related to any health care problem or issue you might have at any time, now or in the future. View abstract. Biol Pharm Bull 2003;26(1):79-83. Z., Qin, B. W., Cheng, J. J., and Miao, H. Effect of Scutellaria flavonoids on KCN-induced damages in rat pheochromocytoma PC12 cells. Jeong, K., Shin, Y. C., Park, S., Park, J. S., Kim, N., Um, J. Y., Go, H., Sun, S., Lee, S., Park, W., Choi, Y., Song, Y., Kim, G., Jeon, C., Park, J., Lee, K., Bang, O., and Ko, S. G. Ethanol extract of Scutellaria baicalensis Georgi prevents oxidative damage and neuroinflammation and memorial impairments in artificial senescense mice. Bezielle selectively targets mitochondria of cancer cells to inhibit glycolysis and OXPHOS. Krskova, Z., Martin, J., Pec, J., and Dusek, J. Limit doses of American skullcap to no more than the package recommendation. Nishioka T, Kawabata J, Aoyama Y. Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis. Tsao, T. F., Newman, M. G., Kwok, Y. Y., and Horikoshi, A. K. Effect of Chinese and western antimicrobial agents on selected oral bacteria. African Journal of Biotechnology 2011;10(26):5182-5192. Analysis of essential oils from different organs of Scutellaria baicalensis. View abstract. View abstract. Ready to start planning your care? Zhou J, Qu F, Yu Y, et al. S. barbata possesses a range of antitumor activities via multiple intracellular targets(20), with major anticancer constituents identified as scutellarin, apigenin5-O--glucopyranoside, apigenin, p-coumaric acid, luteolin and 4-hydroxywogonin(22). Watanabe S, Kitade Y, Maski T, Nishioba M, Satoh K, Nishino H. Effects of lycopene and Sho-saiko-to on hepatocarcinogenesis in a rat model of sponstaneous liver cancer. Zhongguo Zhong.Yao Za Zhi 2001;26(11):768-769. root of Scutellaria baicalensis Georgi. Accessed Sept 30, 2016. Preclinical studies of S. barbata have focused mostly on colon, lung, and liver cancer models. Ju, W. Z., Liu, F., Wu, T., Xia, X. Y., Tan, H. S., Wang, X., and Xiong, N. N. [Simultaneous determination of baicalin and chlorogenic acid in human plasma by UPLC-MS/MS]. Levy RM, Saikovsky R, Shmidt E, et al. Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. View abstract. There have been reports of fever and lung inflammation in people who took Baikal skullcap. View abstract. September 2012. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. In vitro studies suggest that S. barbata has antibacterial(1), antioxidant(15), antimutagenic(2), and anticancer(3)(4)(5)(6)(7)(8)(10)(11)(12) properties. Vitamin D Deficiency: How Much Vitamin D Is Enough? [Study on effect and mechanism of scutellaria baicalensis stem-leaf total flavonoid in regulating lipid metabolism]. Biull.Eksp.Biol Med 1999;128(9):327-329. Therapeutic Research Faculty 2020. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. View abstract. Mu, X., He, G., Cheng, Y., Li, X., Xu, B., and Du, G. Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro. Kaplya, O. From diagnosis to treatment, our experts provide the care and support you need, when you need it. [Effect of Radix scutellariae on the growth and form of Porphyromanus endodontics in vitro]. Liu, W., Mu, R., Nie, F. F., Yang, Y., Wang, J., Dai, Q. S., Lu, N., Qi, Q., Rong, J. J., Hu, R., Wang, X. T., You, Q. D., and Guo, Q. L. MAC-related mitochondrial pathway in oroxylin-A-induced apoptosis in human hepatocellular carcinoma HepG2 cells. Eur J Drug Metab Pharmacokinet. Biochem Biophys Res Commun 9-24-2000;276(2):534-538. Apoptotic effects with the alkaloid scutebarbatine A occurs via cytochrome c and caspase-3/9 upregulation, and Bcl-2 downregulation(28). View abstract. A., Sherstoboev, E. Y., Zueva, E. P., Razina, T. G., Amosova, E. N., and Krylova, S. G. Effect of baikal skullcap extract administered alone or in combination with cyclophosphamide on natural cytotoxicity system in mice with Lewis lung carcinoma. Cancer Res 7-15-2003;63(14):4037-4043. View abstract. Vopr.Onkol. View abstract. Health-related information changes frequently and therefore information contained on this Web site may be outdated, incomplete or incorrect. 2nd ed. Cancer Lett. 2004;50(3):279-285. Altavilla D, Squadrito F, Bitto A, et al. View abstract. In Vivo 2004;18(4):497-503. J Chem Ecol. WebScutellaria Baicalensis Root - China Manufacturers, Factory, Suppliers. Efficacy and safety of flavocoxid, a novel therapeutic, compared with naproxen: a randomized multicenter controlled trial in subjects with osteoarthritis of the knee. Zhao, M., Zhou, Z. T., and Zhang, W. D. [Antifugal susceptibility testing and antifugal traditional Chinese medicines screening of oral Candida isolated from head and neck cancer patients treated with radiotherapy or chemotherapy]. 1997;52(11-12):817-823. View abstract. Ann N Y Acad Sci 2007;1095:521-526. View abstract. Hong, T., Jeong, M. L., Zahn, M., Fay, B. Evid Based Complement Alternat Med. Zhang H, Huang J. View abstract. J Ethnopharmacol. Phytother.Res 2007;21(9):900-903. 2010;17(1):47-54. 11-28-2000;160(2):219-228. View abstract. View abstract. Planta Med 2000;66:70-1. Health Benefits Different apoptotic effects of wogonin via induction of H(2)O(2) generation and Ca(2+) overload in malignant hepatoma and normal hepatic cells. Effects of Mg-ATP on the flavonoid production in the Scutellaria baicalensis Georgii suspension cultures. CAS #:94279-99-9 | EC #:304-845-9. Pasanen MK, Fredrikson H, Neuvonen PJ, Niemi M. Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin. Homma, M., Oka, K., Taniguchi, C., Niitsuma, T., and Hayashi, T. Systematic analysis of post-administrative saiboku-to urine by liquid chromatography to determine pharmacokinetics of traditional Chinese medicine. Extraction of polysaccharides from herbal, Anti-angiogenic effect of the total flavonoids in. Jianjun, J. and Huiru, D. Preparation of high-purity baicalein from Scutellaria baicalensis Georgi. J Altern Complement Med 2002;8(5):567-572. The safety of flavocoxid, a medical food, in the dietary management of knee osteoarthritis. Zhang S, Cheng Z, Huang B, and Li J. View abstract. Z. Check your mobile for SMS (Didn't get the message, repeat Step 1). Drug Metab Dispos 2005;33:537-46. The active ingredient in Baikal skullcap, baicalin, is used in combination with shung hua (ephedra) to treat upper respiratory tract infections. Sichuan.Da.Xue.Xue.Bao.Yi.Xue.Ban. Medications that cause sleepiness and drowsiness are called sedatives. View abstract. View abstract. Chinese skullcap can decrease the blood level of several drugs used to lower cholesterol levels. Hirunuma, M., Shoyama, Y., Sasaki, K., Sakamoto, S., Taura, F., Shoyama, Y., Tanaka, H., and Morimoto, S. Flavone-catalyzed apoptosis in Scutellaria baicalensis. Int J Mol Med 2004;14(4):627-632. View abstract. A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation. View abstract. Eksp.Klin Farmakol. Cancer Lett. Liao, H. L. and Hu, M. K. Synthesis and anticancer activities of 5,6,7-trimethylbaicalein derivatives. Total flavonoids induced increases in DNA fragmentation and mitochondrial pathway apoptosis(30). 1990;36(5):602-607. Chen C, Mireles RJ, Campbell SD, et al. J Ethnopharmacol. Huang, Y., Tsang, S. Y., Yao, X., and Chen, Z. Y. Available at: https://www.cancer.gov/about-cancer/treatment/cam/hp/pc-spes-pdq. View abstract. Common substitutions for Baikal skullcap in Chinese medicine include related plants whose scientific names are Scutellaria viscidula, Scutellaria amonea, and Scutellaria ikoninikovii. Yeh J.H, Chiu H.F, Wang J.S., and et al. View abstract. Contact Dermatitis. Skullcap should not be used during pregnancy or breastfeeding. J AOAC Int 2009;92(3):785-788. Safety, tolerability, pharmacokinetics, and food effect of baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled, single-dose phase I study. Scutellaria baicalensis extract containing baicalin (a flavone, type of flavonoid, is a major bioactive compound) has been used in traditional Chinese medicine to treat conditions of inflammation, hypertension, cardiovascular diseases, etc. 9-7-2009;125(2):286-290. Planta Med 2000;66(8):694-698. In some cases, this might change the effects and side effects of a medication. View abstract. Although Scutellaria baicalensis Georgi is used for antipyretic and antiinflammatory purposes, its whitening effect remains unclear. Integr.Cancer Ther. View abstract. Huang, R. L., Chen, C. C., Huang, H. L., Chang, C. G., Chen, C. F., Chang, C., and Hsieh, M. T. Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis. Protective effect of scutellaria baicalensis stem-leaf total flavonoid against hippocampus neurodamage induced by injection A25-35. View abstract. Planta Med 2003;69(4):300-304. Konig J, Seithel A, Gradhand U, Fromm MF. Hou, Y. C., Lin, S. P., Tsai, S. Y., Ko, M. H., Chang, Y. C., and Chao, P. D. Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats. Kimura, Y., Yokoi, K., Matsushita, N., and Okuda, H. Effects of flavonoids isolated from scutellariae radix on the production of tissue-type plasminogen activator and plasminogen activator inhibitor-1 induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells. This will help them manage your care and keep you safe. reduce wrinkles, smooth skin) but without the side effects (though it seems now that the INCI name of Lanablue was Baikal skullcap (Scutellaria baicalensis) is a plant native to China and Korea. 2011;10(2):184-191. Eur J Pharmacol 4-24-2006;536(1-2):192-199. WebInhibitory effect of skullcap (Scutellaria baicalensis) extract on ovalbumin permeation in vitro and in vivo. Pharmacotherapy 2010;30(7):750, 258e-750, 262e. Biol Pharm Bull 2004;27(10):1580-1583. People with diabetes should not take Chinese skullcap without consulting a doctor as it may lower blood sugar, View abstract. B., Ro, J. Y., and Woo, S. S. Antiallergic herbal composition from Scutellaria baicalensis and Phyllostachys edulis. The effects of acute and repeated oroxylin A treatments on Abeta(25-35)-induced memory impairment in mice. Ong, E. S., Len, S. M., and Lee, A. C. Differential protein expression of the inhibitory effects of a standardized extract from Scutellariae radix in liver cancer cell lines using liquid chromatography and tandem mass spectrometry. View abstract. Planta Med 2010;76(1):76-78. Study on the effects of extracts from Scutellaria baicalensis combined with cisplatin on apoptosis of human ovarian carcinoma cell line SKOV-3. Morgan SL, Baggott JE, Moreland L, et al. Baikal skullcap is also sometimes applied to the skin for psoriasis. Vopr.Onkol. Pediatr Dermatol 2006;23:507-10. View abstract. View abstract. Clin Pharmacol Ther 2007;82:726-33. View abstract. Yao Xue.Xue.Bao. Am J Chin Med 2006;34(2):245-261. Food Chem Toxicol. View abstract. 11-12-2009;126(2):320-331. View abstract. This could increase how much lithium is in the body and result in serious side effects. T Planta Med 2010;76(7):678-682. Some medications are moved by pumps into cells. Studies indicate that aqueous extracts suppressed the growth of lymphoma and myeloma cells. The safety of flavocoxid, a medical food, in the dietary management of knee osteoarthritis. Afr J Tradit Complement Altern Med. 2008;57(3):111-114. Dygai, A. M., Suslov, N. I., Skurikhin, E. G., Churin, A. View abstract. Laboratory studies have shown S. barbata can limit the growth of cancer cells. J Ethnopharmacol. View abstract. Wang, Z. View abstract. View abstract. Kim, D. S., Son, E. J., Kim, M., Heo, Y. M., Nam, J. Kim M, Lee BC. View abstract. View abstract. This Web site Information About Herbs, Botanicals and Other Products is for general health information only. Udintsev, S. N., Razina, T. G., and Iaremenko, K. V. [The antitumor effect of Baikal skullcap]. Flavonoids and scutebarbatines can regulate immune function, with decreases in IL-17, IL-10, FOXP3, TGF-beta1, RORgammat, and IL-6 levels, and increases in IL-2 and IFN-gamma levels(23). 2010;16(2):32-40. Yang, X., Huang, S., Chen, J., Song, N., Wang, L., Zhang, Z., Deng, G., Zheng, H., Zhu, X. Q., and Lu, F. Evaluation of the adjuvant properties of Astragalus membranaceus and Scutellaria baicalensis GEORGI in the immune protection induced by UV-attenuated Toxoplasma gondii in mouse models. CNS.Neurol.Disord Drug Targets. This is especially relevant to macrophages and immune cells. Your Query - This is a community service. Bioorg.Med Chem 8-1-2008;16(15):7516-7524. This Web site is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem. Pharmacol Biochem Behav 2009;92(4):642-648. This is especially relevant to macrophages and immune cells. Acta Pharmacol Sin. 10-18-2009;41(5):578-584. WebScutellaria Baicalensis Extract. Skin contact Rinse skin with water/shower. Therapeutic effect of Scutellaria baicalensis on L-thyroxine-induced hyperthyroidism rats. Kumagai, T., Muller, C. I., Desmond, J. C., Imai, Y., Heber, D., and Koeffler, H. P. Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines. J Interferon Cytokine Res 2008;28(9):571-581. This might increase the side effects of some medications. View abstract. US Food and Drug Administration (FDA). Anesth Analg 2003;97:1724-9. A., and Provalova, N. V. [The modulating effects of preparations of Baikal skullcap (Scutellaria baicalensis) on erythron reactions under conditions of neurotic exposures]. Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. View abstract. Scutellaria barbata should not be confused with Scutellaria baicalensis. Li BQ, Fu T, Gong WH, et al. 4 Physical and Chemicals Properties Scutellaria Baicalensis Root Extract In an ultraviolet (UV) spectral analysis of a Scutellaria baicalensis root extract (aqueous ethanol extract), an absorption peak between 200 and 250 nm and an absorption peak between 250 and 300 nm were It often is used in combination with other botanicals such as PC-SPES and sho-saiko-to. Naunyn-Schmiedeberg Arch Pharmacol 2006;372:432-43. [Study of Scutellaria baicalensis and Baicalin against antimicrobial susceptibility of Helicobacter pylori strains in vitro]. Baicalin also activated caspase-3, resulting in apoptosis of leukemia-derived T cells. Yang, L., Zheng, X. L., Sun, H., Zhong, Y. J., Wang, Q., He, H. N., Shi, X. W., Zhou, B., Li, J. K., Lin, Y., Zhang, L., and Wang, X. Catalase suppression-mediated H(2)O(2) accumulation in cancer cells by wogonin effectively blocks tumor necrosis factor-induced NF-kappaB activation and sensitizes apoptosis. Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others. Ann Intern Med 2012;156:857-60. Arch Dis Child 1993;68:468-71. Tseng-Crank J, Sung S, Jia Q, and et al. A., Ruscetti, F. W., and Wang, J. M. Flavonoid baicalin inhibits HIV-1 infection at the level of viral entry. 2003;34(3):504-506. View abstract. View abstract. Int J Cancer 5-1-2007;120(9):2019-2027. View abstract. 1-8-2007;245(1-2):269-274. J Cell Biochem 12-15-2010;111(6):1629-1641. Before taking Baikal skullcap, talk to your healthcare provider if you take any medications that are changed by the liver. Phase I trial and antitumor effects of BZL101 for patients with advanced breast cancer. Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. The safety of flavocoxid, a medical food, in the dietary management of knee osteoarthritis. Blood 2-15-2008;111(4):2354-2363. Therefore patients who are taking statins should avoid going with this Chinese herb. B., Blach-Olszewska, Z., and Aliev, G. Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? View abstract. View abstract. Taking large amounts of Baikal skullcap along with alcohol might cause too much sleepiness. In vitro and in vivo antitumor activity of scutebarbatine A on human lung carcinoma A549 cell lines. Differential interaction of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors with ABCB1, ABCC2, and OATP1B1. CNS.Neurol.Disord Drug Targets. Different extracts of this herb have been found to kill cancer cells in the body, but human research is pending in this field. Ann Intern Med 2012;156:857-60. This Web site is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem. J Ethnopharmacol. J Ethnopharmacol. View abstract. Call us at 833-347-1665 to make an appointment. Some medications that are moved by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others. View abstract. Zhang H and Huang J. Wang R.T, Zhang J.X, and Dong Y.J. The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion-transporting polypeptide 1B1. J Biomed.Sci 2009;16:27. Adam T, Bursztejn AC, Schmutz JL. Mol Pharmacol 2001;60(3):507-513. Baikal skullcap might slow blood clotting. 6 ):1629-1641, Z. Y D is Enough permeation in vitro cultures upon treatment sodium! ):5182-5192 cisplatin on apoptosis of leukemia-derived T cells drugs used to lower cholesterol levels interaction of reductase... Abcb1, ABCC2, and Woo, S. S. 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